• Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study 

      Al-Jebari, Yahia; Glimelius, Ingrid; Nord, Carina Berglund; Ståhl, Olof; Tandstad, Torgrim; Jensen, Allan; Haugnes, Hege Sagstuen; Daugaard, Gedske; Rylander, Lars; Giwercman, Aleksander (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)
      <i>Background</i> - Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children ...
    • Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era 

      Hellesnes, Ragnhild; Kvammen, Øivind; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-09)
      Using complete information on total treatment burden, this population‐based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway identified 5,625 1‐year TCS diagnosed 1980–2009. Standardized incidence ratios (SIRs) were calculated to evaluate the total and site‐specific incidence of SC compared to the ...
    • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

      Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
      PURPOSE - It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. The aim of this study was to assess the second TC risk, emphasizing the impact of previous TC treatment.<p> <p>PATIENTS AND METHODS - Based on the Cancer Registry of Norway, ...
    • Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P) 

      Löffeler, Sven; Bertilsson, Helena Maria; Müller, Christoph Rainer; Aas, Kirsti; Haugnes, Hege Sagstuen; Aksnessæther, Bjørg Yksnøy; Pesonen, Maiju; Thon, Kristian; Tandstad, Torgrim; Murtola, Teemu; Poulsen, Mads Hvid Aaberg; Nordstrøm, Tobias; Vigmostad, Maria Nyre; Ottosson, Fredrik; Holmsten, Karin; Christiansen, Ola B.; Slaaen, Marit; Haug, Erik Skaaheim; Storås, Anne Holck; Asphaug, Lars; Rannikko, Antti; Brasso, Klaus (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)
      Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs life and improves health-related quality of life (HRQoL) in this age group compared to conservative therapy, which has evolved considerably during the last decade.<p> <p>Study ...
    • Surgical Complications in Postchemotherapy Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumour: A Population-based Study from the Swedish Norwegian Testicular Cancer Group 

      Gerdtsson, Axel; Håkansson, Ulf; Törnblom, Magnus; Jancke, George; Negaard, Helene Francisca Stigter; Glimelius, Ingrid; Halvorsen, Dag; Karlsdottir, Åsa; Haugnes, Hege Sagstuen; Andreassen, Kristine Engen; Larsen, Signe Melsen; Holmberg, Göran; Wahlqvist, Rolf; Tandstad, Torgrim; Cohn-Cedermark, Gabriella; Ståhl, Olof; Kjellmann, Anders (Preprint; Manuskript, 2020-09-08)
      Background - Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of population-based studies.<p> <p>Objective - To assess the complications of bilateral and unilateral PC-RPLND.<p> <p>Design, setting, and participants - A prospective, population-based, ...
    • Thromboembolic events after high-intensity training duringcisplatin-based chemotherapy for testicular cancer: Casereports and review of the literature 

      Thorsen, Lene; Haugnes, Hege Sagstuen; Fosså, Sophie Dorothea; Brydøy, Marianne; Tandstad, Torgrim; Wisløff, Torbjørn; Gjerset, Gunhild Maria; Edvardsen, Elisabeth; Larsen, Karl-Otto; Sandset, Per Morten; Henriksson, Carola; Raastad, Truls; Negaard, Helene Francisca Stigter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)
      The randomized “Testicular cancer and Aerobic and Strength Training trial” (TAST‐trial) aimed to evaluate the effect of high‐intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin‐based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review ...
    • Thromboembolic Events During Treatment with Cisplatin-based Chemotherapy in Metastatic Testicular Germ-cell Cancer 2000–2014: A Population-based Cohort Study 

      Haugnes, Hege S.; Negaard, Helene F.; Negaard, Helene Francisca Stigter; Jensvoll, Hilde; Wilsgaard, Tom; Tandstad, Torgrim; Solberg, Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-15)
      <i>Background</i> - Cisplatin-based chemotherapy (CBCT) in testicular cancer (TC) is associated with elevated venous thromboembolism (VTE) risk, but trials evaluating the safety and efficacy of thromboprophylaxis are lacking.<br><br> <i>Objective</i> - To evaluate the arterial thromboembolism (ATE) and VTE incidence and risk factors during first-line CBCT for metastatic TC, and the effect of ...
    • Validation of a prediction model for post-chemotherapy fibrosis in nonseminoma patients 

      Gerdtsson, Axel; Torisson, Gustav; Thor, Anna; Grenabo Bergdahl, Anna; Almås, Bjarte; Håkansson, Ulf; Törnblom, Magnus; Negaard, Helene Francisca Stigter; Glimelius, Ingrid; Halvorsen, Dag; Karlsdottir, Åsa; Haugnes, Hege Sagstuen; Larsen, Signe Melsen; Holmberg, Göran; Wahlqvist, Rolf; Tandstad, Torgrim; Cohn-Cedermark, Gabriella; Ståhl, Olof; Kjellman, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-02)
      Objective - To validate Vergouwe's prediction model using the Swedish and Norwegian Testicular Cancer Group (SWENOTECA) RETROP database and to define its clinical utility.<p> <p>Materials and methods - Vergouwe's prediction model for benign histopathology in post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) uses the following variables: presence of teratoma in orchiectomy specimen; ...